Use a 4-quart slow cooker sprayed with cooking spray. Add the beans, tomatoes and chiles, corn, bell pepper, onion, cheese, chili powder, and cumin to the crock. Stir well to combine.
In a mixing bowl, whisk together the baking mix, milk, cornmeal, sugar, and egg to form a batter. It will be lumpy. Pour this mixture evenly over the top of the ingredients in the crock.
Sprinkle the paprika on top.
Cover and cook on low for 5-6 hours or on high for about 3 hours. The tamale pie is finished when the cornbread is fully cooked, set in the middle, and has begun to pull away from the sides. Uncover and let it sit in the cooling slow cooker for 10 minutes before cutting.