Preheat the oven to 375°F. Generously butter a 9x13-inch glass baking dish.
Bring a large pot of water to a boil. Add salt and pasta. Cook until al dente, according to package directions. Drain and return pasta to the pot. Add butter and toss until pasta is coated and all the butter has melted. Set aside.
In a medium bowl, add evaporated milk, milk, pumpkin puree, cinnamon, garlic powder, onion powder, salt, pepper, and eggs. Whisk together until the eggs are blended into the mixture. Set aside.
Place a third of the cooked noodles in an even layer in the bottom of the prepared baking dish. Cover noodles evenly with a third of each of the grated cheeses. Repeat two more times with remaining noodles and cheeses. Pour milk mixture evenly over top. If making ahead, stop here and set aside up to 2 hours until ready to bake.
When ready to bake, sprinkle the top cheese layer evenly with breadcrumbs. Bake, uncovered, until the top layer is lightly browned, and cheese is starting to bubble, 35-45 minutes. Let stand 10-15 minutes to set slightly before serving.